How can chitosan be used in tissue engineering?

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The partly hydrophobic, partly polycationic nature of chitosans make them ideally suited as a support for the growth of human cells, e.g. in the form of a hydrogel mimicking the natural environment of human tissues. Simultaneously, the antimicrobial activities of chitosans can prevent microbial contaminations of ex vivo grown cells and tissues. One promising application is the use of chitosan hydrogels for the cultivation of large skin transplants from a small number of cells harvested from healthy skin of a patient with large-scale burns requiring skin grafting.